Description
Sterile solution.
Tris-EDTA + N-Acetyl Cysteine (NAC) buffer with high hygienic strength for dogs and cats.
Tris-EDTA (Ethylene Diammine Tetraacetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm (Ciofu et al, 2017); in combination with Tromethamine (Tris), it damages bacterial cell walls and increases penetration into bacterial membranes; it is well tolerated and non-ototoxic; it acts synergistically with chlorhexidine (Guardabassi et al, 2010). Recently, an in vitro study demonstrated that Tris-EDTA is a more than effective support in the treatment of chronic cases of Pseudomonas otitis with the presence of potential biofilms combined with antibiotics (Pye et al, 2014).
NAC is an N-acetylated derivative of the amino acid cysteine, has mucolytic action, thus destroying the production of exopolysaccharides and thereby weakening the EPS matrix. It has recently been used in eight clinical studies as an adjuvant treatment to destroy mature biofilm and prevent its formation, and has demonstrated an excellent safety and efficacy profile.
The combination of Tris-EDTA and NAC on the skin and in the ear before the application of topical products such as chlorhexidine, antibiotics, synthetic antimicrobial peptides, therefore allows an increase in the permeability of mature biofilm and, consequently, its disintegration, effectively supporting the overcoming of the problem of resistance to the classic antibacterial therapeutic approach.

Instructions for use
1. Press on the top of the bottle until the cap completely breaks.
2. Shake the bottle.
3. Use the syringe provided in the package to withdraw the quantity to be used according to the Veterinarian's instructions.
In the ear canal: irrigate adequately and massage the base of the ear.
On the skin: irrigate until the affected area is completely imbibed.
Repeat the treatment as needed or as directed by the Veterinarian.

Format
120 ml bottle.

Code. PP3310001