{"product_id":"gold-collagen-defence-30-compresse","title":"Gold Collagen Defence 30 Comprimidos","description":"\u003cp\u003e\u003c\/p\u003e\u003ch1\u003eGOLD COLLAGEN DEFENCE\u003c\/h1\u003e \u003cdiv align=\"justify\"\u003e \u003cb\u003eDescrição\u003c\/b\u003e\u003cbr\u003e Suplemento alimentar com uma formulação única de 17 ingredientes ativos. Especialmente formulado para ajudar a pele a combater os radicais livres, prevenir a redução do colagénio e manter a pele, unhas e cabelo saudáveis.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eIngredientes\u003c\/b\u003e\u003cbr\u003e Vitamina C (ácido L-ascórbico), cloridrato de glucosamina (glucosamina HCl), extrato seco de chá verde (40% EGCG, \u003ci\u003eCamellia sinensis\u003c\/i\u003e (L.) Kuntze), vitamina E (alfa-tocoferol), vitamina B3 (niacina), gluconato de zinco, hialuronato de sódio, coenzima Q10 (ubidecarenona), beta-caroteno, vitamina B6 (cloridrato de piridoxina), vitamina A (acetato de retinilo), gluconato de cobre, extrato de pimenta preta (95% piperina - \u003ci\u003ePiper nigrum\u003c\/i\u003e L.), luteína, astaxantina (\u003cb\u003esoja\u003c\/b\u003e), L-selenometionina, vitamina H (biotina); agentes de volume: celulose microcristalina, fosfato de cálcio; antiaglomerantes: estearato de magnésio vegetal, dióxido de silício; estabilizador: carboximetilcelulose sódica reticulada; agentes de revestimento: hidroxipropilmetilcelulose, celulose microcristalina, ácido esteárico; corantes alimentares: E101, E172.2.\u003cbr\u003e \u003cbr\u003e Sem \u003cb\u003eglúten\u003c\/b\u003e e \u003cb\u003elactose\u003c\/b\u003e.\u003cbr\u003e Adequado a vegetarianos e vegans.\u003cbr\u003e Não contém conservantes, açúcares nem edulcorantes artificiais.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eCaracterísticas nutricionais\u003c\/b\u003e\u003cbr\u003e \u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"1\" width=\"400\"\u003e \u003ctr align=\"center\"\u003e\n\n\u003ctd\u003e\u003cb\u003eValores médios\u003c\/b\u003e\u003c\/td\u003e\n\n\u003ctd\u003e\u003cb\u003ePor dose diária (1 comprimido)\u003c\/b\u003e\u003c\/td\u003e\n\n\u003ctd\u003e\u003cb\u003eVRN*\u003c\/b\u003e\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eVitamina C\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e80 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e100%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eGlucosamina\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e30 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eExtrato de chá verde\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e20 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eVitamina E (alfa-tocoferol)\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e10 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e83%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eVitamina B3 (niacina)\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e10 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e63%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eZinco\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e10 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e100%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eÁcido hialurónico\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e5 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eCoenzima Q10 (ubidecarenona)\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e3 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eBeta-caroteno\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e2 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eVitamina B6\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e1,5 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e107%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eVitamina A (RE)\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e1 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e125%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eCobre\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e1 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e100%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eExtrato de pimenta preta\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e1 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eLuteína\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e0,5 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eAstaxantina\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e0,5 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e-\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eSelénio\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e0,07 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e127%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003ctr\u003e\n\n\u003ctd\u003eVitamina H (biotina)\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e0,05 mg\u003c\/td\u003e\n\n\u003ctd align=\"center\"\u003e100%\u003c\/td\u003e\n\n\n\u003c\/tr\u003e \u003c\/table\u003e *VRN: valores de referência do nutriente\u003cbr\u003e \u003cbr\u003e \u003cb\u003eModo de utilização\u003c\/b\u003e\u003cbr\u003e Recomenda-se tomar um comprimido por dia às refeições ou de acordo com a indicação médica, durante pelo menos um mês, preferencialmente por um período mais longo para obter resultados mais duradouros.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eAvisos\u003c\/b\u003e\u003cbr\u003e Não exceder a dose diária recomendada. Manter fora do alcance de crianças com menos de 3 anos de idade. Os suplementos não devem ser utilizados como substitutos de uma dieta variada. Consulte o seu médico antes de tomar o produto caso esteja a tomar outros suplementos alimentares, ou em caso de alergias alimentares, toma de medicamentos ou se estiver sob cuidados médicos. Consulte o seu médico se observar uma reação indesejada. Consulte o médico em caso de gravidez ou amamentação antes de tomar Gold Collagen Defence.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eConservação\u003c\/b\u003e\u003cbr\u003e Conservar a uma temperatura inferior a 30°C, longe da luz solar direta e do calor, e proteger da humidade. O prazo de validade refere-se ao produto conservado corretamente na embalagem original e intacta.\u003cbr\u003e Validade com embalagem intacta: 24 meses\u003cbr\u003e \u003cbr\u003e \u003cb\u003eFormato\u003c\/b\u003e\u003cbr\u003e Embalagem de 30 comprimidos\u003cbr\u003e \u003cbr\u003e \u003cb\u003eBibliografia\u003c\/b\u003e\u003cbr\u003e Baumann L: Skin ageing and its treatment. The Journal of pathology 2007, 211:241- 51.\u003cbr\u003e Guercio-Hauer C, Macfarlane DF, Deleo VA: Photodamage, photoaging and photoprotection of the skin. American family physician 1994, 50:327-32, 34.\u003cbr\u003e Thiele JJ: Oxidative targets in the stratum corneum. A new basis for antioxidative strategies. Skin pharmacology and applied skin physiology 2001, 14 Suppl 1:87-91.\u003cbr\u003e Levine RL, Stadtman ER: Oxidative modification of proteins during ageing. Experimental gerontology 2001, 36:1495-502.\u003cbr\u003e Bickers DR, Athar M: Oxidative stress in the pathogenesis of skin disease. The Journal of investigative dermatology 2006, 126:2565-75.\u003cbr\u003e Rani AJ, Mythili SV: Study on total antioxidant status in relation to oxidative stress in type 2 diabetes mellitus. Journal of clinical and diagnostic research: JCDR 2014, 8:108-10.\u003cbr\u003e Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham CO, 3rd, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, Oddis CV, Wolfe F, Lisse J, Furst DE, Reda DJ, Moskowitz RW, Williams HJ, Clegg DO: The effect of glucosamine and\/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine\/chondroitin arthritis intervention trial. Arthritis and rheumatism 2008, 58:3183-91.\u003cbr\u003e Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO, 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR, Jr., Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ: Glucosamine, chondroitin sulphate, and the two in combination for painful knee osteoarthritis. The New England journal of medicine 2006, 354:795-808.\u003cbr\u003e Murad H, Tabibian MP: The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneousageing: a preliminary study. The Journal of dermatological treatment 2001, 12:47-51.\u003cbr\u003e Yuan JP, Peng J, Yin K, Wang JH: Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Molecular nutrition \u0026amp; food research 2011, 55:150-65.\u003cbr\u003e Miki W: Biological functions and activities of animal carotenoids. Pure and Applied Chemistry 1991, 63 141–6.\u003cbr\u003e Matsuno T: Xanthophylls as precursors of retinoids. Pure and Applied Chemistry 1991, 63: 81–8.\u003cbr\u003e Lee SJ, Bai SK, Lee KS, Namkoong S, Na HJ, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, Lee SK, Kim YM: Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappa B activation. Molecules and cells 2003, 16:97-105.\u003cbr\u003e Goto S, Kogure K, Abe K, Kimata Y, Kitahama K, Yamashita E, Terada H: Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochimica et biophysica acta 2001, 1512:251-8.\u003cbr\u003e Yamashita E: Suppression of post-UVB hyperpigmentation by topical astaxanthin from krill. Fragrance Journal 1995, 14:180–5.\u003cbr\u003e Arakane K: Superior skin protection via astaxanthin. Carotenoid Science 2002, 5:21–4.\u003cbr\u003e Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R, Yamada A, Tsuchiya H, Kanamura K, Yamashita E, Kogure K: Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage. Journal of pharmaceutical sciences 2012, 101:2909-16.\u003cbr\u003e Biswal S: Oxidative stress and astaxanthin: The novel supernutrient carotenoid. International Journal of Health \u0026amp; Allied Sciences 2014, 3:147-53.\u003cbr\u003e Cho S, Lee DH, Won CH, Kim SM, Lee S, Lee MJ, Chung JH: Differential effects of low-dose and high-dose beta-carotene supplementation on the signs of photoaging and type I procollagen gene expression in human skin in vivo. Dermatology 2010, 221:160-71.\u003cbr\u003e Lee J, Jiang S, Levine N, Watson RR: Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proceedings of the Society for Experimental Biology and Medicine Society for Experimental Biology and Medicine 2000, 223:170-4.\u003cbr\u003e Kopcke W, Krutmann J: Protection from sunburn with beta-Carotene--a metaanalysis. Photochemistry and photobiology 2008, 84:284-8.\u003cbr\u003e Littarru GP, Tiano L: Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular biotechnology 2007, 37:31-7.\u003cbr\u003e Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M, Ichihashi M: Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. BioFactors 2008, 32:237-43.\u003cbr\u003e Zhang M, Dang L, Guo F, Wang X, Zhao W, Zhao R: Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1alpha production and melanin synthesis in vitro. International journal of cosmetic science 2012, 34:273-9.\u003cbr\u003e Muta-Takada K, Terada T, Yamanishi H, Ashida Y, Inomata S, Nishiyama T, Amano S: Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells. BioFactors 2009, 35:435-41.\u003cbr\u003e Forester SC, Lambert JD: The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Molecular nutrition \u0026amp; food research 2011, 55:844-54.\u003cbr\u003e Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM: Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evidence-based complementary and alternative medicine : eCAM 2005, 2:301-8.\u003cbr\u003e Lacroix S, Bouez C, Vidal S, Cenizo V, Reymermier C, Justin V, Vicanova J, Damour O: Supplementation with a complex of active nutrients improved dermal and epidermal characteristics in skin equivalents generated from fibroblasts from young or aged donors. Biogerontology 2007, 8:97-109.\u003cbr\u003e Madhan B, Krishnamoorthy G, Rao JR, Nair BU: Role of green tea polyphenols in the inhibition of collagenolytic activity by collagenase. International journal of biological macromolecules 2007, 41:16-22.\u003cbr\u003e Katiyar SK: Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Current drug targets Immune, endocrine and metabolic disorders 2003, 3:234-42.\u003cbr\u003e Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB: Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al] 2005, 31:855- 60; discussion 60.\u003cbr\u003e Watanabe-Kamiyama M, Shimizu M, Kamiyama S, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M: Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. Journal of agricultural and food chemistry 2010, 58:835-41.\u003cbr\u003e Aito-Inoue M, Lackeyram D, Fan MZ, Sato K, Mine Y: Transport of a tripeptide, Gly-Pro-Hyp, across the porcine intestinal brush-border membrane. Journal of peptide science: an official publication of the European Peptide Society 2007, 13:468-74.\u003cbr\u003e Toshihide S: Clinical effects of dietary hyaluronic acid on dry, rough skin. . Aesthetic Dermatology 2002, 12:109-20.\u003cbr\u003e Kawada C, Yoshida T, Yoshida H, Matsuoka R, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O: Ingested hyaluronan moisturizes dry skin. Nutrition journal 2014, 13:70.\u003cbr\u003e Roberts RL, Green J, Lewis B: Lutein and zeaxanthin in eye and skin health. Clinics in dermatology 2009, 27:195-201.\u003cbr\u003e Gonzalez S, Astner S, An W, Goukassian D, Pathak MA: Dietary lutein\/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice. The Journal of investigative dermatology 2003, 121:399-405.\u003cbr\u003e Lee EH, Faulhaber D, Hanson KM, Ding W, Peters S, Kodali S, Granstein RD: Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression. The Journal of investigative dermatology 2004, 122:510-7.\u003cbr\u003e Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R, Morganti P: Beneficial long-term effects of combined oral\/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin pharmacology and physiology 2007, 20:199-210.\u003c\/div\u003e","brand":"MINERVA RESEARCH LABS","offers":[{"title":"Default Title","offer_id":57388645187928,"sku":"974163964","price":15.96,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0968\/9301\/0264\/files\/974163964.jpg?v=1779979733","url":"https:\/\/www.globalpharmacy.it\/pt\/products\/gold-collagen-defence-30-compresse","provider":"Global Pharmacy ","version":"1.0","type":"link"}