{"product_id":"tris-nac-soluzione-sterile-otologica-120-ml","title":"Tris Nac Sterile Otological Solution 120 ml","description":"\u003cp\u003e\u003c\/p\u003e\u003ch1\u003eTris-NAC\u003c\/h1\u003e \u003cdiv align=\"justify\"\u003e\n\n\u003cb\u003eDescription\u003c\/b\u003e\u003cbr\u003e Sterile solution.\u003cbr\u003e Tris-EDTA + N-Acetyl Cysteine (NAC) buffer with high hygienic strength for dogs and cats.\u003cbr\u003e Tris-EDTA (Ethylene Diammine Tetraacetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm (\u003ci\u003eCiofu et al, 2017\u003c\/i\u003e); in combination with Tromethamine (Tris), it damages bacterial cell walls and increases penetration into bacterial membranes; it is well tolerated and non-ototoxic; it acts synergistically with chlorhexidine (\u003ci\u003eGuardabassi et al, 2010\u003c\/i\u003e). Recently, an in vitro study demonstrated that Tris-EDTA is a more than effective support in the treatment of chronic cases of Pseudomonas otitis with the presence of potential biofilms combined with antibiotics (\u003ci\u003ePye et al, 2014\u003c\/i\u003e).\u003cbr\u003e NAC is an N-acetylated derivative of the amino acid cysteine, has mucolytic action, thus destroying the production of exopolysaccharides and thereby weakening the EPS matrix. It has recently been used in eight clinical studies as an adjuvant treatment to destroy mature biofilm and prevent its formation, and has demonstrated an excellent safety and efficacy profile.\u003cbr\u003e The combination of Tris-EDTA and NAC on the skin and in the ear before the application of topical products such as chlorhexidine, antibiotics, synthetic antimicrobial peptides, therefore allows an increase in the permeability of mature biofilm and, consequently, its disintegration, effectively supporting the overcoming of the problem of resistance to the classic antibacterial therapeutic approach.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eInstructions for use\u003c\/b\u003e\u003cbr\u003e 1. Press on the top of the bottle until the cap completely breaks.\u003cbr\u003e 2. Shake the bottle.\u003cbr\u003e 3. Use the syringe provided in the package to withdraw the quantity to be used according to the Veterinarian's instructions.\u003cbr\u003e In the ear canal: irrigate adequately and massage the base of the ear.\u003cbr\u003e On the skin: irrigate until the affected area is completely imbibed.\u003cbr\u003e Repeat the treatment as needed or as directed by the Veterinarian.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eFormat\u003c\/b\u003e\u003cbr\u003e 120 ml bottle.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eCode.\u003c\/b\u003e PP3310001\u003c\/div\u003e","brand":"NEXTMUNE ITALY SRL","offers":[{"title":"Default Title","offer_id":57340152643928,"sku":"975062908","price":22.52,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0968\/9301\/0264\/files\/975062908.jpg?v=1779331080","url":"https:\/\/www.globalpharmacy.it\/en\/products\/tris-nac-soluzione-sterile-otologica-120-ml","provider":"Global Pharmacy","version":"1.0","type":"link"}