{"product_id":"siringa-preriempita-intra-articolare-cingal-4-ml-22mg-ml-acido-reticolato-con-4-5-mg-ml-triamcinolone-esacetonide","title":"Cingal Pre-filled Intra-Articular Syringe 4 ml 22mg\/ml Cross-linked Hyaluronic Acid with 4.5 mg\/ml Triamcinolone Hexacetonide","description":"\u003cp\u003e\u003cfont size=\"7\"\u003e\u003cb\u003e\u003ci\u003eC1\u003csup\u003e+\u003c\/sup\u003eNGAL\u003c\/i\u003e\u003c\/b\u003e\u003c\/font\u003e\u003cbr\u003e \u003cbr\u003e \u003cfont size=\"2\"\u003eCROSS-LINKED SODIUM HYALURONATE 88 mg\u003cbr\u003e WITH TRIAMCINOLONE HEXACETONIDE 18 mg\u003cbr\u003e FOR INTRA-ARTICULAR INJECTION\u003c\/font\u003e\u003cbr\u003e \u003cbr\u003e \u003c\/p\u003e\u003cdiv align=\"justify\"\u003e\n\n\u003cb\u003eMaterials\u003c\/b\u003e\u003cbr\u003e Cingal is an opaque, whitish, sterile, single-use suspension of a cross-linked hyaluronic acid (HA) gel with added corticosteroid (triamcinolone hexacetonide).\u003cbr\u003e \u003cbr\u003e \u003cb\u003ePresentation\u003c\/b\u003e\u003cbr\u003e HA is an essential component of the extracellular matrix and is found in high concentrations in the synovial fluid of joints. \u003cbr\u003e Hyaluronic acid is naturally biocompatible, and its degradation process follows a normal physiological pathway. \u003cbr\u003e HA is responsible for the viscoelastic properties of synovial fluid. \u003cbr\u003e The synovial fluid of joints affected by osteoarthritis has a lower concentration of HA and a reduced molecular weight of HA compared to healthy joints. Sodium hyaluronate supplements (viscosupplements) have been shown to be well-tolerated in synovial joints affected by osteoarthritis and work to reduce pain and improve function through lubrication and mechanical support.\u003cbr\u003e The added corticosteroid triamcinolone hexacetonide has an anti-inflammatory action to provide short-term pain relief when used in an intra-articular injection of an osteoarthritis-affected joint.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eSterility\u003c\/b\u003e\u003cbr\u003e Sterile product (steam sterilization).\u003cbr\u003e \u003cbr\u003e \u003cb\u003eValidity\u003c\/b\u003e\u003cbr\u003e 36 months (from date of manufacture).\u003cbr\u003e \u003cbr\u003e \u003cb\u003eClassification\u003c\/b\u003e\u003cbr\u003e Class III Medical Device (Directive 93-42-EEC).\u003cbr\u003e \u003cbr\u003e \u003cb\u003eRegulatory Status\u003c\/b\u003e\u003cbr\u003e CE Mark (Notified Body 0120).\u003cbr\u003e \u003cbr\u003e Cingal is indicated as a viscoelastic supplement or as a replacement for synovial fluid in human joints.\u003cbr\u003e Cingal is suitable for rapid and long-term relief of symptoms of joint diseases such as osteoarthritis.\u003cbr\u003e Cingal provides long-term symptom relief through lubrication and mechanical support, and also short-term pain relief thanks to triamcinolone hexacetonide.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eContraindications\u003c\/b\u003e\u003cbr\u003e Cingal is composed of cross-linked hyaluronic acid, triamcinolone hexacetonide, and inactive ingredients. The following pre-existing conditions may lead to relative or absolute contraindications to the use of Cingal:\u003cbr\u003e • hypersensitivity to the active substance or to any of the excipients contained in Cingal;\u003cbr\u003e • pre-existing infections in the skin area of the intended injection site;\u003cbr\u003e • known infection in the target joint;\u003cbr\u003e • known systemic coagulation disorders.\u003cbr\u003e Triamcinolone hexacetonide, the accessory medicinal substance, is contraindicated in cases of:\u003cbr\u003e • active tuberculosis;\u003cbr\u003e • herpes simplex keratitis;\u003cbr\u003e • acute psychosis;\u003cbr\u003e • systemic mycoses and parasitoses (strongyloides infections).\u003cbr\u003e \u003cbr\u003e \u003cb\u003eInstructions for use\u003c\/b\u003e\u003cbr\u003e Cingal is injected directly into the chosen joint space by means of a sterile, single-use hypodermic needle of appropriate gauge.\u003cbr\u003e Healthcare personnel must attach the sterile needle to the Cingal syringe using an aseptic technique approved by the healthcare facility.\u003cbr\u003e Recommended needle sizes for knee injections are 18-21 gauge.\u003cbr\u003e The final choice of needle for any procedure is the responsibility of the physician.\u003cbr\u003e The physician must ensure that the needle has properly penetrated the synovial space of the joint before injecting Cingal.\u003cbr\u003e \u003cbr\u003e \u003cb\u003ePresentations\u003c\/b\u003e\u003cbr\u003e Cingal is a sterile preparation supplied in a 4.0 ml single-use glass syringe.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eStorage conditions\u003c\/b\u003e\u003cbr\u003e Store at a temperature between 2 and 25°C.\u003cbr\u003e Avoid freezing. \u003cbr\u003e Before using Cingal, the refrigerated product must be brought to room temperature (this process takes approximately 20 to 45 minutes).\u003cbr\u003e \u003cbr\u003e \u003cb\u003eCode\u003c\/b\u003e VRCN1\u003c\/div\u003e","brand":"ABIOGEN PHARMA SPA","offers":[{"title":"Default Title","offer_id":57673133850968,"sku":"971279601","price":160.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0968\/9301\/0264\/files\/971279601.jpg?v=1783604293","url":"https:\/\/www.globalpharmacy.it\/en\/products\/siringa-preriempita-intra-articolare-cingal-4-ml-22mg-ml-acido-reticolato-con-4-5-mg-ml-triamcinolone-esacetonide","provider":"Global Pharmacy","version":"1.0","type":"link"}